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10,15,18,23 One trial specifically investigated BD, 11 while another 19 included a small subgroup of nine patients with bipolar depression alongside its primary MDD population

No large-scale randomized controlled trial has specifically studied sexual side effects as a primary endpoint

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The standard care for tendon, ligament, muscle, and bone injuries remains the foundation, and its a foundation built on decades of solid evidence: Conservative treatment : Rest, physical therapy, progressive loading, anti-inflammatory management, and activity modification remain first-line approaches for most musculoskeletal injuries